Human Genomic Association Studies: A Primer for the Infectious Diseases Specialist
نویسندگان
چکیده
منابع مشابه
The Effect of Climate Changes on human Bacterial infectious diseases
A growing body of documents shows that rising average global temperatures can be one of several causes of disease emergence and reemergence among human and animal populations. In this regard, climate mostly affects diseases caused by pathogens that spend part of their lifecycle outside of the host, exposed to the environment like water-borne diseases, food-borne pathogens, and vector-borne zoon...
متن کاملEthical Criteria for Human Challenge Studies in Infectious Diseases
Purposeful infection of healthy volunteers with a microbial pathogen seems at odds with acceptable ethical standards, but is an important contemporary research avenue used to study infectious diseases and their treatments. Generally termed ‘controlled human infection studies’, this research is particularly useful for fast tracking the development of candidate vaccines and may provide unique ins...
متن کاملGenome-wide association studies and susceptibility to infectious diseases.
Progress in genomics and the associated technological, statistical and bioinformatics advances have facilitated the successful implementation of genome-wide association studies (GWAS) towards understanding the genetic basis of common diseases. Infectious diseases contribute significantly to the global burden of disease and there is robust epidemiological evidence that host genetic factors are i...
متن کاملA Simple Genome Walking Strategy to Isolate Unknown Genomic Regions Using Long Primer and RAPD Primer
Background: Genome walking is a DNA-cloning methodology that is used to isolate unknown genomic regions adjacent to known sequences. However, the existing genome-walking methods have their own limitations. Objectives: Our aim was to provide a simple and efficient genome-walking technology. Material and Methods: In this paper, we dev...
متن کاملGenome-wide association studies: a primer.
There have been nearly 400 genome-wide association studies (GWAS) published since 2005. The GWAS approach has been exceptionally successful in identifying common genetic variants that predispose to a variety of complex human diseases and biochemical and anthropometric traits. Although this approach is relatively new, there are many excellent reviews of different aspects of the GWAS method. Here...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2007
ISSN: 0022-1899,1537-6613
DOI: 10.1086/518247